A research team at the Central Food Technological Research Institute at Mysore in India, has demonstrated the effectiveness of a new multi-step ulcer preventive activity.
A phenol-bound Pectic Polysaccharide, derived from a plant species, Decalepis hamiltonii, was used in treating multiple complications which one suffers, when encountered with ulcer. This plant has been found in abundance in India.
The polysaccharide, apart from reducing swim/alcohol stress induced ulcers, also normalizes oxidative stress and stress-induced damage to the stomach tissue and antioxidant enzymes that necessitate the management of oxidative stress, generated during gastric ulceration. It also helps in recovery of the damaged mucosal epithelium, which safeguards stomach tissue, by preventing the entry of ulcerogenics, such as Helicobacter pylori.
The identified polysaccharide, which also exhibited potent antioxidant activity, including scavenging of free radicals, and inhibition of growth of Helicobacter pylori, confirmed its ability to inhibit various gastric ulcerations directly.
Hence, the researchers concluded that the bioactive polysaccharide with its defined sugar composition, present in the swallow root, exhibited multi-potent free radical scavenging antioxidant, anti-Helicobacter pylori property, and gastric-mucosal protective activities.
Swallow root is also found to be non-toxic, when compared to other known anti-ulcer drugs.